BDBM10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3

SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O

InChI Key InChIKey=OUZWUKMCLIBBOG-UHFFFAOYSA-N

Data  378 KI  4 IC50  16 Kd

PDB links: 9 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 10882   

TargetCarbonic anhydrase(Sulfurihydrogenibium sp. (strain YO3AOP1))
Universit£

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  9.30nMAssay Description:Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  39.4nMAssay Description:Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  39.4nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Cryptococcus neoformans var. grubii (Filobasidiell...)
Universite Degli Studi Di Firenze

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  87nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Saccharomyces cerevisiae)
Balikesir University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  98.4nMAssay Description:Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  105nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Helicobacter pylori (strain G27))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  155nMAssay Description:Inhibition of Helicobacter pylori recombinant CAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Anopheles gambiae)
University Of Tampere And Tampere University Hospital

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  185nMAssay Description:Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophilaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  387nMAssay Description:Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Mycobacterium tuberculosis)
Kochi Medical School

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  594nM ΔG°:  -8.35kcal/molepH: 8.3 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  740nMAssay Description:Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophilaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Candida albicans (Yeast))
Universite Degli Studi Di Firenze

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  1.07E+3nM ΔG°:  -8.00kcal/molepH: 8.3 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Candida albicans (Yeast))
Universite Degli Studi Di Firenze

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  1.07E+3nMAssay Description:inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Candida albicans (Yeast))
Universite Degli Studi Di Firenze

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of Candida albicans recombinant Carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Methanobacterium thermoautotrophicum)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  5.35E+3nMAssay Description:Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Saccharomyces cerevisiae)
Balikesir University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed